serum response element การใช้

• ELK1 and SAP1a have been shown to form ternary complexes with SRF on the serum response elements ( SRE ) located in the c-fos promoter.
• SAP1a is a nuclear protein stimulating transcription via the c-fos serum response element, and additionally via an Ets binding site independently of the serum response factor.
• Proteins of the TCF subfamily form a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene.
• The protein encoded by this gene is a serine / threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin focal adhesions, and the activation of the c-fos serum response element.